Abstract Oral mucositis is a painful condition that occurs in patients who have undergone haematopoietic stem-cell transplantation (HSCT) and has a huge impact on their quality of life. The objective of this study was to examine the extent to which interleukin-6 (IL-6) and tumour necrosis factor alpha (TNF-α) are associated with oral health quality of life among patients who underwent HSCT. A. C. Camargo Cancer Center patients were evaluated over 20 months at 4 different time-points: a) at patient admission (M1); b) on the day of infusion of HSC (M2); c) 12 and 20 days after the first day of the conditioning regimen for autologous and allogeneic transplantation, respectively (M3); and d) 30 days after the first day of the conditioning regimen (M4). Mucositis clinical evaluations were performed using World Health Organization (WHO) criteria. Oral health quality of life was measured using the Oral Health Impact Profile short form (OHIP-14), Oral Mucositis Quality of Life (OMQoL) and Patient-Reported Oral Mucositis Symptom (PROMS) scales. Correlations between clinical data and quality of life scores were examined. STATA 11.0 was used to perform the statistical analyses (5% level of significance). Eighty-two patients participated in the study; 62.2% were male, 28.05% had multiple myeloma, and the mean age was 48.49 years (SD 13.76). Higher scores (worse quality of life) were observed as mucositis scores increased, but the results were not significant. The OMQoL had a high correlation with OHIP-14 (0.8377), but the correlation between the PROMS scale and the OHIP-14 was lower (0.6643). Higher concentrations of IL-6 and TNF-α were associated with worse quality of life, according to all indices (p < 0.05). Oral mucositis was associated with quality of life scores (p < 0.01).

INTRODUÇÃO : Com a preocupação em antecipar o acesso ao resultado de radiografias intrabucais, o processamento radiográfico é muitas vezes negligenciado, comprometendo a qualidade da imagem. OBJETIVO : O objetivo deste trabalho foi avaliar a influência da interrupção do processo de fixação no contraste radiográfico e na densidade base e velamento (DBV) em 3 marcas comerciais de filmes periapicais. MATERIAL E MÉTODO : Foram realizadas 90 radiografias de um stepwedge de alumínio e uma placa de chumbo para cada marca, e as mesmas foram divididas de acordo com o tempo de imersão inicial no fixador em: grupo controle (sem interrupção na fixação), 5, 10, 20, 30 e 40 segundos. Durante o processamento, os filmes tiveram a fixação interrompida e foram expostos à luz de um negatoscópio por 1 minuto, e então completaram o tempo de fixação de 10 minutos. As radiografias foram digitalizadas e analisadas no software Image Tool 3.0. RESULTADO : O filme Kodak(r) não apresentou diferenças estatísticas significantes entre os grupos, enquanto que o filme Agfa(r) apresentou diferença na DBV em relação ao grupo de 5 segundos, e o filme Dentix(r) apresentou diferença estatística em todos os grupos comparando-os ao grupo controle. CONCLUSÃO : Sob as condições estudadas, o filme Kodak(r) não sofreu influência da interrupção da fixação na DBV e no contraste da imagem, possibilitando o acesso antecipado ao resultado do exame radiográfico, enquanto que o filme Agfa(r) necessita de pelo menos 10 segundos de fixação inicial e o filme Dentix(r) obtém melhores resultados quando não interrompido o processo de fixação.

INTRODUCTION : With the interest in anticipating access to the result of intraoral radiography, the radiographic processing is frequently neglected, compromising image quality. OBJECTIVE : The aim of this study was to evaluate the influence of interrupting the fixation process on the radiographic contrast and base-plus-fog density (BPFD) in three brands of periapical films. MATERIAL AND METHOD : Ninety radiographs were taken of an aluminum stepwedge and a lead plate for each brand, and they were divided according to the time of initial immersion in the fixative in: control group (without interrupting the fixing), 5, 10, 20, 30 and 40 seconds. During processing, films had the fixing stage stopped and were exposed to a negatoscope for 1 minute, then the fixation time of 10 minutes was completed. The radiographs were digitized and exported to Image Tool 3.0.software. RESULT : Kodak(r) film showed no statistically significant differences between groups, while Agfa(r) film presented difference in BPFD compared with Group 5 seconds, and Dentix(r) film showed statistical difference in all groups in comparison with the control group. CONCLUSION : Under the conditions studied, Kodak(r) film is not influenced by disruption of fixation as regards BPFD and image contrast, enabling early access to the results of radiographs, whereas Agfa(r) film requires at least 10 seconds of initial fixation, and Dentix(r) film obtains better results when the process of fixation is not interrupted.